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Pyridine-2-carboxylic acid (picolinic acid) has been extensively studied due to its magnetic, structural, medicinal and biological properties. Picolinic acid plays a vital role in the absorption of zinc and has neuro-protective, immunological and antiproliferative effects within the body. The multifunctional ligands containing N and O-donors, such as picolinic acid, are of great interest since they are significant from the industrial point of view. 4-(Trifluoromethyl)pyridine-2-carboxylic acid, a derivative of picolinic acid, could be used to synthesise a new polymeric copper(II) complex as a ligand[1].

[1] Hatice Vural, Metin Orbay. “Synthesis, crystal structure, spectroscopic investigations and DFT calculations of the copper(II) complex of 4-(Trifluoromethyl)pyridine-2-carboxylic acid.” Journal of Molecular Structure 1146 (2017): Pages 669-676.